A new advanced vegetarian glucosamine supplement knocked out the competition by improving joint function and comfort in as few as five days, up to 28 percent faster than leading brands, according to a clinical study.
The study compared Advanced Joint Health Complex to the nation's leading brands, Osto Bi-Flex®, Nature Made® Triple Flex, and Schiff® Move Free®. The key ingredient, a patent-
pending fast-acting form of Boswellia extract, worked in as few as five days--faster than claimed by the other brands.
In addition, participants were also asked to rate their level of comfort and ease of motion before and after taking the products for 90 days. Results showed that the new joint health complex (scroll linked page for details and short video) was rated to be 45 percent more effective at long-term joint support and provides up to 31 percent more ease of motion. The study was conducted July 15, 2011.(1)
The best glucosamine supplement of those studied was manufactured and marketed by the Shaklee Corporation, a recognized dietary supplement industry pioneer, founded in California in 1956. Their joint health product contains 1500 mg of corn-sourced glucosamine hyrdrochloride, and 100 mg of a fast-acting form of boswellia serrata herb extract resin in a complex also including Vitamin C, zinc, copper and manganese.
It is promoted as 100 percent shellfish free, 100 percent vegetarian and 100 percent chondroitin free (for better glucosamine absorption) and that its proprietary ingredient blend promotes mobility, enhances flexibility and improves joint function.(1A)
In another clinical study, researchers found that chondroitin sulfate interferes with glucosamine absorption.(2) The new glucosamine supplement is 100% chondroitin free. The leading competitive brands above all contain chondoitin and glucosamine sourced from shellfish. Nature Made® also includes artificial colors. Advanced Joint Health Complex contains no artificial flavors, sweeteners, or preservatives and is gluten free. It is packaged in a recycable bottle and no bisphenol-A is used in packaging.
There is considerable controversy regarding absorption of chondroitin. Absorption of glucosamine is 90% to 98%, but chondroitin absorption is only 0% to 13% because chondroitin is 50 to 300 times larger than glucosamine. Chondroitin may be too large to be delivered to cartilage cells. In addition, there may be purity and identity problems with some chondroitin products, some of which have tested as subpotent. (3)
Glucosamine supplements are most often sourced from the outer skeletons of shellfish, which may cause allergic reactions in those with shellfish allergies, or a possible worsening of asthma symptoms. (3) However, Advanced Joint Health Complex parallels recent trends exhibiting increased popularity of glucosamine from corn; it works universally but also targets vegetarians, individuals allergic to shellfish, and a specific population segment who strictly follow Jewish food habits.
Osto Bi-Flex®, Nature Made® Triple Flex, and Schiff® Move Free® all contain glucosamine sourced from shellfish as of label comparisons June 12, 2017.
Glucosamine is an amino sugar that serves as a key building block of proteoglycans, structural components of cartilage and the fluid between bones that provides lubrication.
Numerous studies published over the years indicate glucosamine supplementation helps improve range of motion, mobility, and flexibility. Multiyear studies also suggest glucosamine supplmentation improves long-term joint health. Advanced Joint Health Complex features glucosamine hydrochloride, the most concentrated source of glucosamine.
Glucosamine is made from glucose and the amino acid glutamine found naturally in the body but its production slows with aging (4)--when people need it the most.
In long-term clinical trials glucosamine supplements are thought to help repair damaged cartilage by replenishing the body’s own diminishing supply of glucosamine.
Natural glucosamine hydrochloride supplements outmatched popular prescription Celebrex in relieving moderate-to-extreme osteoarthritis knee pain, knee swelling, knee stiffness and inflexibility in the 2006 Glucosamine/chondroitin Arthritis Invervention Trial (GAIT) study.
GAIT was a large, randomized, placebo-controlled trial conducted across the United States with results published in three different journals in 2006, 2008 and 2010. Funded by the National Center for Complementary and Alternative Medicine (NCCAM), its conclusions found that glucosamine and chondroitin supplements are extremely safe, however did not provide significant relief from mild osteoartitis pain among all particpants. (5)
The evidence for the effectiveness of glucosamine supplement treatments, with or without chondroitin, has never been strong, which is why they're considered "complementary". But doctors understandably prescribe them: they don't do any harm, for one thing; whereas some of the medical treatments for joint pain can cause dangerous side-effects. Long-term use of anti-inflammatory drugs is associated with stomach and heart problems. The clincher, as far as prescribers are concerned, is probably good old patient choice. That is to say, patients believe in glucosamine. They want it; it does no harm: why not give it a go? (6)
Glucosamine comes in several forms, including glucosamine hydrochloride, glucosamine sulfate and others. Clinical studies show glucosamine benefits the body by metabolizing each about the same. There is no conclusive evidence to suggest that one form is better than another.
Glucosamine hydrochloride is a more concentrated source and is bioavailable and sodium free (sulfate form may contain up to 35% salt). It is every bit as well absorbed as sulfate, yet does not use salt to stabilize the supplement as does the sulfate version. Glucosamine hydrochloride may also help the body make chondroitin sulfate (another substance necessary for healthy cartilage).(7)
Many people who need glucosamine supplements have low sodium restrictions for other health conditions, such as high blood pressure. Advanced Joint Health Complex, Osto Bi-Flex®, Nature Made® Triple Flex, and Schiff® Move Free® all use glucosamine hydrochloride in their joint supplements.
The Shaklee corporation has always been driven by science and responsible innovation. They are recognized industry-wide as the scientific leader. They have more scientists on staff than any other nutritional company by far. In this regard, they dwarf their competition.
From a purely scientific point of view, they've decided to use glucosamine in combination with plant-sourced boswellia but not in combination with animal-sourced chondroitin. Many other companies combine chondroitin with their glucosamine supplements.
The source of most raw chondroitin is the meat packing industry, mostly imported from China. Chondroitin supplements are prepared from animal cartilage like bovine trachea, pig and shark cartilage.
Osto Bi-Flex®, Nature Made® Triple Flex, and Schiff® Move Free® all contain chondroitin in their glucosamine supplements.
Glucosamine is widely available as a nutritional supplement in different formulations. Recently liquid glucosamine supplements have appeared on the market. There are many brand names, many claims, many pronouncements and a lot of hype. They’re promoted with a few testimonials, and may have a paid doctor’s recommendation, but little if any solid clinical substance.
Those that claim clinical testing, refer to previous clinical trials on glucosamine tablets. I found no human studies on the liquid products themselves. All liquid supplements should be viewed with caution until valid scientific clinical research is conducted. You must do your homework before buying any natural product.
Dietary supplements are loosely regulated, which has accounted for quality problems. Remember, under the Food and Drug Administration (FDA) dietary supplement industry regulations (Current Good Manufacturing Practices), manufacturers can market products without proving efficacy. They don't have to work, gang, for the FDA to approve them! Shaklee Corporation voluntarily operates as if it were a pharmaceutical company, where efficacy must be proved before it can be sold. That's what impresses me about Shaklee.
From other pages on this site you may be aware that my husband and I both have osteoarthritis. We no longer use prescription or non prescription drugs of any kind to manage arthritis symptoms.
Frankly, we've achieved surprisingly good results through natural herbal supplements alone. We're very happy because we're getting our money’s worth without compromising our health from drug side effects.
The difference in Shaklee products is they're always safe, always work, and always green and 'beyond organic'. In keeping with that tradition, their Complex for Joint Health is:
My husband and I believe we’ve found the best glucosamine supplement available. We don’t have to worry about ingredient purity and potency or side effects--we’ve chosen the right company with an ironclad guarantee (if it doesn't work, get your money back).
For natural relief of osteoarthritis and rheumatoid arthritis, I confidently recommend this scientifically-advanced Joint Complex.
Note: For information on two other products synergistically designed for pain by Shaklee scientists, click on the following link (which also includes our arthritis stories): The Pain Trio.
1. Product bulletin, New Advanced Joint Health Complex, Shaklee Corporation, http://www.shaklee.net/pws/library/products/20281_jointhealthbulletin.pdf
1A. Product Catalog, Shaklee Corporation. Joint Health Complex Fall 2017, page 39 2. Dahmer S et al. Glucosamine. Am Fam Physician. 2008 Aug 15;78(4):471-6. PMID: 18756654
3. Benedikt H. Chondroitin sulfate: the new arthritis therapy. Nat Pharm, 1997;1(8):1,22.
4. Wong, C. Glucosamine for Natural Arthritis Relief, About.com September 26, 2011 (updated).
5. National Center for Complementary and Alternative Medicine (NCCAM), Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT), 2006 primary and 2008/2010 ancillary study results (links to three journal abstracts) http://nccam.nih.gov/research/results/gait/
6. Brown, A.M., Glucosamine supplements for arthritis do not work, new study shows, article, Health and Lifestyle, updated Sept. 17, 2010
7. Gaber, C; Day, C., Why Do I Feel This Way?, 2nd Edition, p 146, 2005
Glucosamine Supplement Disclaimer: Health statements on this page have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease
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