Anti Aging Secrets Discovered
In Cellular Anti Aging Tonic
Ingredients Support Heart Health, Brain Health,
and Joint Health in Laboratory Studies
Unlocked anti aging secrets reveal that resveratrol—a substance found in red wine—and a muscadine super grape may hold the keys to remarkably prolonged cellular life that helps combat the diseases of aging including arthritis. This breakthrough science is now incorporated in an unprecedented new longevity supplement that has shot to the top of the market.
Launched in August, 2008, this cellular anti-aging dietary supplement has captured the attention of people across America. Developed by the number one natural nutrition company in the U.S., the product is regarded as the world’s best anti aging supplement.
Scientists and the general public have become aware of the compelling research on resveratrol and its ability to extend lifespan in many different laboratory studies. Indeed, resveratrol has been referenced in over 2,500 research citations by the National Library of Medicine, including studies conducted by Harvard University, the National Cancer Institute, and the National Institute on Aging.
For centuries, scientists had been trying to discover the secrets to longer life and better health. New anti aging research reveals that natural substances from the plant world may influence the biological changes related to aging in positive ways at the cellular level including joint health, heart and brain health, cardiovascular function and more.
What anti aging secrets has modern science uncovered?
Science had not cracked anti aging secrets in the past. .The pre-1990 “old view” of aging was simply that the body wears out and there’s nothing you can do about it. Anti aging discoveries by the Anti-Aging Laboratory at Harvard University School of Medicine and other independent scientists have changed that view.
In laboratory studies, anti aging secrets were uncovered that point to the four key mechanisms of cellular aging:
The genesis of the new cellular anti-aging tonic coincided with a landmark research study published in the journal Nature in 2006. This laboratory study surfaced the potential of resveratrol to address two key mechanisms of cellular aging, including improving mitochondrial biogenesis and activating genetic regulators of longevity pathways.
Numerous laboratory studies, including those cited at the end of this page, confirm an effect of resveratrol on helping to protect against a third mechanism of cellular aging, the protection and repair of DNA damage.
New anti aging tonic positively impacts all four key mechanisms of cellular aging
In laboratory studies, the new anti aging tonic fights the four key mechanisms of cellular anti aging and more:
- It helps protect and repair cellular DNA
- It positively impacts genetic regulators
- It promotes mitochondrial biogenesis
- It slows Advanced Glycation End Products (AGE) protein formation
In laboratory studies, the product’s ingredients are identified with the following health benefits*:
- It supports heart health and cardiovascular function
- It supports brain health
- It supports immune function
- It promotes cellular longevity
- It promotes good health and well-being
- It supplies antioxidants; fights free radicals
- It increases cellular energy
Beyond resveratrol -- anti aging secrets behind the proprietary polyphenol blend
The manufacturer’s scientists went beyond resveratrol in the creation of the new cellular anti aging tonic by creating a unique and patent-pending polyphenol blend that adds to the power of resveratrol. While resveratrol addresses 3 of the four key mechanisms of aging, it is not very effective in addressing the formation of AGE proteins which can compromise cellular integrity and longevity.
The proprietary polyphenol blend includes compounds from the muscadine grape (a so-called super grape because of its size and the fact it’s the only grape found in nature containing an extra chromosome which scientists believe greatly enhances is potential health benefits) that has been shown to be ten times more powerful than resveratrol alone at addressing this 4th mechanism of cellular aging.
In collaboration with scientists from the University of Georgia, the manufacturer’s scientists employed a bioassay-guided process, which resulted in a patent-pending super grape extract with ellagic acid, a polyphenol not found in ordinary grapes. Ellagic acid is thought to be responsible for many of the unique cellular anti-aging actions of the super grape in the new supplement.
In addition, the extract supplies other potent polyphenols affecting cellular longevity pathways, such as phenolic acids, ellagitannins, anthocyanins, and proanthocyanidins.
Included in the discovered secrets of anti aging, scientists identified in laboratory studies that the ingredients found in the new supplement activates genetic regulators of cellular longevity pathways, which may have positive effects on DNA, cellular health, and metabolism.
Secrets behind the supplement’s 98% resveratrol content
In order to create a resveratrol content in a dietary supplement that exceeds anything else on the market the company’s scientists were successful in sourcing the purest and most potent natural resveratrol at a content no less than 98%. This percentage by far exceeds anything on the market today.
In fact, this cellular anti aging tonic is the most complex product ever developed in the 54 year history of the manufacturer because of the challenges for its science team to develop a new extraction process and incorporate it into the production of a highly concentrated and potent liquid formula.
And finally, the manufacturer was able to secure the entire output from the largest and best growers in the world of the muscadine super grape, guaranteeing its exclusivity.
The result is a remarkable dietary supplement with ingredients that have been laboratory tested to address four key mechanisms of cellular aging and the company has filed patents to protect this exclusive and innovative polyphenol formulation.
Secrets of anti-aging uncovered by the featured supplement
The featured cellular anti aging tonic is all-natural, patent-pending and represents breakthroughs in cellular anti aging research that’s absolutely exclusive to the number one natural nutrition company. It has no artificial flavors, colors, sweeteners, or preservatives.
The product is in liquid form and comes in a specially designed bottle that guarantees freshness during shipment. The recommended serving is one teaspoon daily, preferably with a meal (breakfast or lunch is recommended) and delivers 1390 mg of its patent-pending resveratrol blend. Bottles (opened and unopened) should be refrigerated for optimal freshness and quality.
My husband and I have used this product since its introduction in August, 2008 and we believe its improved our joint health, well being and overall energy in remarkable ways. Try a one or two months supply, and decide for yourself.
*Disclaimer: Health statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Citations of key studies that contributed to unlocking anti aging secrets
To help review the science contributed to unlocking anti aging secrets and supporting the manufacturer’s claims, we’ve included the citations of key studies that have been used to validate and support the most important claims made. This includes the manufacturer’s statement that “in laboratory studies the product’s ingredients have been shown to impact four key mechanisms of cellular aging.”
Anti aging secrets: Helps protect and repair cellular DNA
- Usha, S., Irudayan, M.J., Mlahi, R., “Interaction of Resveratrol and Genistein with Nucleic Acids”, Journal of Biochemistry and Molecular Biology, Vol 38, No. 2, March 2005, pp. 198-205
- Niture, S., Velu, C., Smith, Q., Bhat, J., Srivenugopal, K, “Increased Expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventive natural products in human lymphocytes and tumor lines,”Carcinogenesis, Vol 28, No. 2, pp 378-389, 2007
- Yang, S., Irani, K., Heffron, S., Jurnack, F., Meyskens, F., “Alterations in the expressions of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor” Molecular Cancer Therapeutics, 4(12_, December 2005.
- Zahid, M., Gaikwad, N.W., Rogan, E.G., Cavalieri, E.L., “Inhibition of depurinating estrogen-DNA adduct formation by natural compounds,” Chemical Research in Toxicology, 20 (12): 1947-53, December 2007
- Chakraborty, S., Roy, M., Bhattacharya, R.K., “Prevention and repair of DNA damage by selected phytochemicals as measured by single cell gel electrophoresis,” Environmental Pathology, Toxicology, and Oncology, 2004; 23(3): 215-26
- Gatz, S.A., Keimling, M., Baumann, C., Dort, T., Debatin, K.M., Fulda, S., Wiesmuller, L., “Resveratrol modulates DNA double-strand break repeair pathways in an ATM/ATR-p53- and –Nbs1-dependent manner”, Carcinogenesis, 2008, Mar; 29(3): 51927. Epub 2008 Jan 3.
Anti aging secrets: Positively impacts genetic regulators
Pearson, K., Baur, J., Lewis, K., Peshkin, L. et al., “Resveratrol Delays Age-Related Deterioration and Mimics Transriptional Aspects of Dietary Restriction without Extending Life Span,” Cell Metabolism, 2008
- Barger, J.L., Kayo, T., Pugh, T.D., Prolla, T.A., Weindruch, R., “Short term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart”, Experimental Gerontology, 2008, doi: 10.1016/j.exger.2008.06.013
- Barger, J., Kayo, T., Vann, J., Arias, E., Wang, J., Hacker, T., Raederstorff, D., Morrow, J., Leeuwenburgh, C.., Allison, D., Saupe, K., Cartee, G., Weindruch, R., Prolla, T., “A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Paramenters in Mice, “ PLoS ONE, 3(6): e2264, doi:10.1371/journal.pone.0002264
- Howitz, K.T. Bitterman, K.J., Cohen, H.Y., Lamming, D.W., Lavu, S., Wood, J.H., Chung, P., Kisielewski, A., Zhang, L.L., Scherer, B., Sinclair, D.A., “Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan”, Nature 2003 nov 11; 425(6954): 191-6. Epub 2003 Aug 24
Anti aging secrets: Promotes mitochondrial biogenesis
- Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., et al. “Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1a”, Cell, Vol 127, 1109-1122, December 15, 2006
- Dasgupta, B., Milbrandt, J., “Resveratrol stimulates AMP kinase activity in neurons”, Proceedings of the National Academy of Sciences, Vol 104, No. 17, April 24, 2007
- St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J., Rhee, J., Jager, S., Handschin, C., et al., “Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators”, Cell, Volume 127, 397-408, October 20, 2006
- Civitarese, A., Carling, S., Heibronn, L., Hulver, M., Ukropcova, B., Deutsch, W., Smith, S., Ravussin, E., “Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans”, PLoS Medicine, Vol 4, issue 3, March 2007
- Lopez-Lluch, G., Irusta, P., Navas, P., deCabo, R., “Mitochondrial biogenesis and healthy aging”, Experimental Gerontology Vol 43, 813-819, 2008
Anti aging secrets: Slows AGE protein formation
- Farrar, J., artle, D., Hargrove, J., Greenspan, P., “Inhibition of protein glycation by skins and seeds of the muscadine grape”, BioFactors, Vol 30, 193-200, 2007
- Hudson, T., Hartle, D., Hursting, S., Nunez, N., Wang, T., Young, H., Arany, P., Green, J., “Inhibition of Prostate Cancer Growth by Muscadine Grape Skin Extract and Resveratrol through Distinct Mechanisms”, Cancer Research 2007, 6717), September 1, 2007
- Bralley, E., Greenspan, P., Hargrove, J., Hartle, D., “Inhibition of Hyarluronidase Activity by Vitas rotundifolia (Muscadine) Berry Seeds and Skins”, Pharmaceutical Biology, Vol 45, No. 9, pp 667-673, 2007
- Ramasamy, R., Vannucci, S., Shi Du Tan, S., Herold, K., Yan, S., Schmidt, A., “Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation”, Glycobiology, vol. 15. No. 7 pp. 16R-28R, 2005
Guidance on Resveratrol dosage and Safety
- Reagan-Shaw., S., Nihal, M., Ahmad, N., “Dose translation from animal to human studies revisited”, The FASEB Journal, fj.07-9574LSF, published online October 17, 2007
- Baur, J., Pearson, K., Price, N., Jamieson, H, Lerin, C., Kalra, A., et al. “Resveratrol improves health and survival of mice on a high calorie diet”, Nature Volume 444, November 16, 2006
- Juan, M., Vinardell, M., Planas, J., “The Daily Oral Administration of High Doeses of trans-Resveratrol to Rats for 28 Days is Not Harmful”, The Journal of Nutrition, 132:257-260, 2002
- Crowell, J., Korytko, P., Morrissey, R., Boorth, M., Levine, B., “Resveratrol-Associated Renal Toxicity,” Toxicological Sciences, 82, 614-619, 2004
- Boocock, D., Faust, G., Patel, K., Schinas, A., Brown, V., Ducharme, M., et al., “Phase 1 Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent”, Cancer Epidemiology Biomarkers & Prevention, 2007, 16(6), June, 2007
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